HIST1H2AL
HIST1H2AL
HIST1H2AL is a gene that encodes a member of the histone H2A family. Histones are proteins that play a crucial role in packaging DNA into chromatin, which is essential for the regulation of gene expression and maintenance of genomic stability.
Structure[edit | edit source]
The HIST1H2AL gene is located on chromosome 6 in humans. It consists of a coding region that produces the histone protein and regulatory regions that control its expression.
Function[edit | edit source]
Histone H2A proteins, including HIST1H2AL, are involved in the organization of DNA into nucleosomes, the basic units of chromatin. They also participate in various cellular processes such as DNA replication, repair, and transcriptional regulation.
Clinical Significance[edit | edit source]
Mutations in the HIST1H2AL gene have been associated with certain types of cancer and other diseases. Dysregulation of histone proteins can lead to aberrant gene expression patterns and contribute to the development of various disorders.
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
