HIST1H2BE
HIST1H2BE
HIST1H2BE is a gene that encodes a member of the histone H2B family. Histones are proteins that play a crucial role in packaging DNA into structural units called nucleosomes. The HIST1H2BE gene is located on chromosome 6 in humans.
Function[edit | edit source]
The protein encoded by HIST1H2BE is a core component of nucleosomes, which are the basic units of chromatin. Chromatin is the complex of DNA and proteins that make up chromosomes. Histone proteins like HIST1H2BE help regulate gene expression by controlling access to the DNA.
Structure[edit | edit source]
HIST1H2BE belongs to the histone H2B family, which includes several variants. This gene produces a specific variant of the histone H2B protein. The structure of HIST1H2BE is characterized by its ability to interact with other histones and DNA to form nucleosomes.
Clinical Significance[edit | edit source]
Mutations in the HIST1H2BE gene have been associated with various diseases, including cancer. Dysregulation of histone proteins can lead to abnormal gene expression patterns, which may contribute to the development of cancer and other disorders.
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
