HIST1H3B

Protein HIST1H3B PDB 1aoi

HIST1H3B is a gene that encodes a member of the histone H3 family. Histones are basic nuclear proteins that are responsible for the nucleosome structure of chromosomal fiber in eukaryotes. This particular gene is part of a cluster of histone genes located on chromosome 6.

Function

Histones play a critical role in transcriptional regulation, DNA repair, DNA replication, and chromosomal stability. The protein encoded by HIST1H3B is a core component of the nucleosome, which is the basic repeating unit of chromatin.

Structure

The protein product of HIST1H3B is a histone protein that forms the octameric nucleosome core around which DNA is wrapped. This gene is part of a cluster of histone genes that are located on the short arm of chromosome 6.

Clinical Significance

Mutations in histone genes have been associated with various diseases, including cancer. Alterations in histone proteins can lead to changes in chromatin structure and gene expression, which can contribute to the development of cancer.

Interactions

The protein encoded by HIST1H3B interacts with various other proteins involved in chromatin remodeling and gene regulation. These interactions are essential for the proper functioning of the nucleosome and chromatin structure.