HIST1H3C

Protein HIST1H3C PDB 1aoi

HIST1H3C

HIST1H3C is a gene that encodes a member of the histone H3 family. Histones are proteins that play a crucial role in packaging DNA into structural units called nucleosomes. The HIST1H3C gene is located on chromosome 6 in humans.

Function

The protein encoded by HIST1H3C is a core component of nucleosomes, which are the basic units of chromatin. Chromatin is the complex of DNA and proteins that make up chromosomes. Histones like HIST1H3C help regulate gene expression by controlling access to the DNA.

Structure

HIST1H3C is a variant of the histone H3 protein. Histone H3 proteins are highly conserved and play a central role in chromatin structure and function. The specific sequence of HIST1H3C contributes to its unique properties and functions within the nucleosome.

Role in Disease

Mutations in histone genes, including HIST1H3C, have been associated with various diseases, including cancer. Dysregulation of histone expression or function can lead to abnormal gene expression patterns and contribute to the development of cancer and other disorders.