HIST1H4B

Protein HIST1H4B PDB 1aoi

HIST1H4B

HIST1H4B is a gene that encodes a protein belonging to the histone family. Histones are proteins that play a crucial role in packaging DNA into structural units called nucleosomes. These nucleosomes are further organized into chromatin, which is essential for the regulation of gene expression and other cellular processes. The HIST1H4B gene is located on chromosome 6 in humans and is part of a cluster of histone genes. This gene specifically codes for the histone H4B protein, which is one of the core histones involved in forming the nucleosome structure. Histone H4B, along with other histones, helps in compacting DNA and regulating access to genetic information. Mutations or dysregulation of HIST1H4B and other histone genes can lead to various diseases, including cancer. Abnormalities in histone proteins can disrupt the normal packaging of DNA, affecting gene expression patterns and potentially contributing to the development of cancerous cells. Research on histones, including HIST1H4B, is ongoing to understand their roles in health and disease. By studying the functions of histones and their impact on gene regulation, scientists aim to uncover potential therapeutic targets for various conditions. In summary, HIST1H4B is a gene that codes for the histone H4B protein, playing a crucial role in DNA packaging and gene regulation. Understanding the functions of histones like HIST1H4B is essential for unraveling the complexities of cellular processes and diseases.