HIST1H4C

Protein HIST1H4C PDB 1aoi

HIST1H4C

HIST1H4C is a gene that encodes a member of the histone H4 family. Histones are proteins that play a crucial role in packaging DNA into structural units called nucleosomes. The HIST1H4C gene is located on chromosome 6 in humans.

Structure

The HIST1H4C gene consists of a specific sequence of nucleotides that encode the histone H4C protein. This protein is composed of amino acids that form the histone H4 protein variant C.

Function

Histone proteins, including HIST1H4C, are essential components of chromatin, the complex of DNA and proteins found in the nucleus of eukaryotic cells. Histones help regulate gene expression by compacting DNA into chromatin and modulating access to specific regions of the genome.

Role in Epigenetics

Epigenetic modifications, such as histone acetylation and methylation, can alter the structure of chromatin and influence gene expression. The HIST1H4C gene may be subject to epigenetic regulation, impacting its function in chromatin organization and gene regulation.

Clinical Significance

Aberrant expression or mutations in histone genes, including HIST1H4C, have been associated with various diseases, including cancer. Understanding the role of histone proteins in disease pathogenesis may provide insights for developing targeted therapies.