HIST1H4D

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Protein HIST1H4D PDB 1aoi

HIST1H4D

HIST1H4D is a gene that encodes a member of the histone H4 family. Histones are proteins that play a crucial role in packaging DNA into structural units called nucleosomes. The HIST1H4D gene is located on chromosome 6 in humans.

Structure

The HIST1H4D gene consists of a coding region that produces the histone H4 protein. This protein is composed of a core region and a flexible tail. The core region is involved in forming the nucleosome structure, while the tail can undergo various post-translational modifications that regulate gene expression.

Function

Histone H4 proteins, including the one encoded by HIST1H4D, are essential components of chromatin, the complex of DNA and proteins in the cell nucleus. These proteins help compact and organize DNA, as well as regulate access to genetic information during processes such as transcription and DNA replication.

Role in Disease

Aberrant expression or mutations in histone genes, including HIST1H4D, have been associated with various diseases, including cancer. Dysregulation of histone proteins can impact chromatin structure and gene expression patterns, contributing to the development and progression of cancer.