HIST1H4E

Protein HIST1H4E PDB 1aoi

HIST1H4E

HIST1H4E is a gene that encodes a member of the histone H4 family. Histones are proteins that play a crucial role in packaging DNA into structural units called nucleosomes. The HIST1H4E gene is located on chromosome 6 in humans.

Function

The protein encoded by HIST1H4E is a core component of nucleosomes, which are the basic units of chromatin structure. Nucleosomes consist of DNA wrapped around histone proteins, including histone H4. Histone H4 proteins help regulate gene expression by controlling access to the DNA.

Structure

The HIST1H4E gene produces a protein that is composed of amino acids arranged in a specific sequence. This protein interacts with other histones and DNA to form nucleosomes. The structure of histone H4 is highly conserved across species and plays a critical role in maintaining chromatin organization.

Role in Epigenetics

Epigenetic modifications, such as histone acetylation and methylation, can alter the structure of chromatin and influence gene expression. Histone H4 proteins, including those encoded by HIST1H4E, are subject to various post-translational modifications that can impact chromatin dynamics and gene regulation.

Clinical Significance

Mutations in genes encoding histone proteins, including HIST1H4E, have been associated with various diseases, including cancer. Dysregulation of histone modifications can lead to aberrant gene expression patterns and contribute to the development of cancer and other disorders.