HIV drug resistance
HIV Drug Resistance
HIV drug resistance is a phenomenon that occurs when the Human Immunodeficiency Virus (HIV) changes its structure in a way that makes it less susceptible or resistant to the drugs designed to inhibit its replication. This can lead to treatment failure and the progression of HIV/AIDS.
Mechanism of Resistance[edit | edit source]
HIV drug resistance develops due to the high mutation rate of the virus. HIV replicates rapidly, producing billions of new viruses each day. During this replication process, the virus often makes mistakes, or mutations, in its genetic code. Some of these mutations can result in changes to the virus's structure that make it less susceptible to antiretroviral therapy (ART).
Types of Resistance[edit | edit source]
There are two main types of HIV drug resistance: primary and secondary. Primary resistance occurs when a person is initially infected with a drug-resistant strain of HIV. Secondary resistance, also known as acquired resistance, develops over time in individuals who are undergoing ART due to the selection pressure exerted by the drugs.
Testing for Resistance[edit | edit source]
Resistance testing is recommended for all individuals diagnosed with HIV before starting ART. This testing can help determine which drugs the virus is likely to be resistant to, allowing for the selection of the most effective treatment regimen.
Management of Resistance[edit | edit source]
Management of HIV drug resistance involves changing to a different ART regimen. This is typically done under the guidance of a healthcare provider, who will consider factors such as the person's treatment history, the results of resistance testing, and the potential side effects of different drugs.
Prevention of Resistance[edit | edit source]
Prevention of HIV drug resistance involves adherence to ART. Missing doses of medication can allow the virus to replicate more freely, increasing the chance of resistance developing. Other prevention strategies include regular monitoring of viral load and resistance testing.
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Contributors: Prab R. Tumpati, MD
