HLA-DQB1

HLA-DQB1 is a gene that provides instructions for making a protein that plays a critical role in the immune system. The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

Function

The HLA-DQB1 gene belongs to the HLA class II, which are involved in the immune system's ability to distinguish between self and non-self. The proteins produced from this gene are located on the surface of cells, where they help the immune system recognize foreign substances.

Clinical significance

Variations in the HLA-DQB1 gene have been associated with a variety of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and celiac disease.

See also

• Human leukocyte antigen
• Autoimmune disease
• Type 1 diabetes
• Rheumatoid arthritis
• Celiac disease

External links

• HLA-DQB1 at NCBI

HLA-DQB1 Resources
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