HLA-DR
HLA-DR is a part of the HLA system, a group of genes in humans that plays a crucial role in the immune system. The HLA-DR gene provides instructions for making a protein that plays a critical role in the immune system. HLA-DR is a type of human leukocyte antigen (HLA) and belongs to the MHC class II group.
Function[edit | edit source]
HLA-DR is involved in the immune system's response to foreign substances. It does this by presenting peptides (small pieces of proteins) from outside the cell to the immune system. This triggers an immune response, including the production of antibodies.
Structure[edit | edit source]
The HLA-DR molecule is a heterodimer, meaning it is made up of two different proteins. These proteins are encoded by two different genes: HLA-DRA, which encodes the alpha chain, and HLA-DRB, which encodes the beta chain. The alpha chain is constant, while the beta chain can vary, leading to different HLA-DR types.
Role in Disease[edit | edit source]
Certain variations of the HLA-DR gene are associated with an increased risk of developing certain autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and type 1 diabetes. In these diseases, the immune system mistakenly attacks the body's own cells.
See Also[edit | edit source]
| HLA-DR Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
