HLA-DRA

HLA-DRA is a gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-DRA is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

Function

The HLA-DRA gene belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Clinical significance

Mutations in the HLA-DRA gene are associated with increased susceptibility to different autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus.

See also

• Human leukocyte antigen
• Autoimmune disease
• Rheumatoid arthritis
• Systemic lupus erythematosus

External links

• HLA-DRA at the US National Library of Medicine Medical Subject Headings (MeSH)