HLA-E
HLA-E is a human leukocyte antigen that is part of the Major Histocompatibility Complex (MHC) class I molecules. It is encoded by the HLA-E gene and is expressed in almost all cells. HLA-E plays a crucial role in the immune system, particularly in the regulation of natural killer cells.
Function[edit | edit source]
HLA-E binds to a subset of peptides derived from the leader sequences of other MHC class I molecules and presents these peptides to the T cells and natural killer cells. This interaction plays a significant role in the immune response, as it helps the immune system distinguish between self and non-self cells.
Clinical significance[edit | edit source]
Alterations in the HLA-E gene have been associated with various diseases. For instance, certain HLA-E alleles have been linked to an increased susceptibility to HIV infection and progression to AIDS. Moreover, HLA-E polymorphisms have been implicated in autoimmune diseases, such as rheumatoid arthritis and type 1 diabetes.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- HLA-E at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD