He Jiankui affair
He Jiankui affair refers to a highly controversial event in the field of genetics and bioethics that occurred in November 2018, when Chinese scientist He Jiankui announced that he had created the world's first genetically edited babies. This announcement was made at the Second International Summit on Human Genome Editing in Hong Kong. He Jiankui claimed to have used the CRISPR-Cas9 gene-editing technology to modify the embryos of twin girls, known by the pseudonyms Lulu and Nana, to make them resistant to HIV by disabling the CCR5 gene, which is a pathway for HIV to infect cells. The scientific community and the public were both shocked and alarmed by the announcement, leading to widespread ethical, social, and scientific debates.
Background[edit | edit source]
CRISPR-Cas9 is a revolutionary gene-editing tool that allows scientists to cut and paste DNA with high precision. While it has the potential to correct genetic defects and prevent diseases, its application in human embryos raises significant ethical concerns, particularly regarding consent, the welfare of the edited individuals, and the potential for unintended consequences or off-target effects. Prior to He Jiankui's announcement, the consensus in the scientific community was that gene editing in human embryos for reproductive purposes was not yet safe or ethical to proceed with.
The Experiment[edit | edit source]
He Jiankui, a former associate professor at the Southern University of Science and Technology in Shenzhen, China, used CRISPR-Cas9 to edit the embryos of seven couples during fertility treatments. The father in each couple was HIV-positive, which was reportedly the rationale for targeting the CCR5 gene, as disabling it could theoretically confer resistance to HIV. The experiment led to one pregnancy resulting in the birth of twin girls.
Ethical and Scientific Criticism[edit | edit source]
The announcement was met with immediate criticism from the global scientific community. Critics argued that the experiment was medically unnecessary, as there are other ways to prevent HIV transmission to offspring, and that it posed unjustifiable risks to the children. Furthermore, there were concerns about the lack of transparency, as the work had not been published in a peer-reviewed journal at the time of the announcement. Ethical concerns were also raised about the consent process and the long-term welfare of the edited children.
Legal and Professional Consequences[edit | edit source]
In response to the outcry, Chinese authorities launched an investigation into He Jiankui's work. In December 2019, He Jiankui was convicted by a Chinese court for practicing medicine without a license, among other charges, and was sentenced to three years in prison and fined. The incident also prompted calls for clearer regulations and oversight of gene editing technologies worldwide.
Impact on Research and Ethics[edit | edit source]
The He Jiankui affair has had a profound impact on the field of genetics and bioethics, sparking a global debate on the governance of gene editing technologies. It has led to increased scrutiny of ethical standards and regulatory frameworks to prevent similar incidents. The affair has also highlighted the need for international cooperation and dialogue to address the ethical and social implications of rapidly advancing biotechnologies.
See Also[edit | edit source]
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