Hepadnaviridae

Hepadnaviridae is a family of viruses. Humans, apes, and birds serve as natural hosts. There are currently seven species in this family, divided among two genera. Diseases associated with this family include: hepatitis B, cirrhosis, and hepatocellular carcinoma.

Taxonomy[edit | edit source]

The family Hepadnaviridae is divided into two genera:

Genus: Orthohepadnavirus
Genus: Avihepadnavirus

Structure[edit | edit source]

Viruses in Hepadnaviridae are enveloped, with spherical geometries. The diameter is around 42 nm. Genomes are circular, around 3.2kb in length.

Life Cycle[edit | edit source]

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the DNA-mediated DNA replication model. DNA-templated transcription is the method of transcription. The virus exits the host cell by budding, and tubule-guided viral movement. Humans, apes, and birds serve as the natural host. Transmission routes are sexual, blood, and contact.

Clinical[edit | edit source]

The most well-known member of this family is the Hepatitis B virus, which is a major cause of viral hepatitis, cirrhosis, and hepatocellular carcinoma.

References[edit | edit source]

External links[edit | edit source]

Hepadnaviridae Resources
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