Hepoxilin A3

Hepoxilin A3

0Hepoxilin A3 is a metabolite of arachidonic acid that is produced by the lipoxygenase pathway. It is a member of the hepoxilin family of bioactive lipids, which are known for their diverse biological activities.

Biosynthesis

Hepoxilin A3 is synthesized from arachidonic acid by the action of 12-lipoxygenase, an enzyme that is found in platelets and neutrophils. The enzyme catalyzes the insertion of oxygen into arachidonic acid to form a hydroperoxy intermediate, which is then converted to hepoxilin A3 by a series of enzyme-catalyzed reactions.

Biological activities

Hepoxilin A3 has been shown to have a variety of biological activities. It is a potent chemotactic agent for neutrophils, and it has been implicated in the regulation of inflammation and immune response. Hepoxilin A3 also has been shown to modulate ion transport in the intestinal epithelium, suggesting a role in the regulation of electrolyte balance.

Clinical significance

The role of hepoxilin A3 in human disease is not fully understood, but it has been implicated in a number of pathological conditions. Elevated levels of hepoxilin A3 have been found in the bronchoalveolar lavage fluid of patients with asthma, suggesting a role in the pathogenesis of this disease. Hepoxilin A3 also has been implicated in the pathogenesis of inflammatory bowel disease and cystic fibrosis.

See also

• Arachidonic acid
• Lipoxygenase
• Hepoxilin
• Inflammation
• Immune response

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