Hereditary Disease Foundation

Nancy Wexler; current president of the HDF

Hereditary Disease Foundation

The Hereditary Disease Foundation (HDF) is a non-profit organization dedicated to the funding of scientific research aimed at the treatment, cure, and prevention of genetic diseases. Founded in 1968, the foundation has been at the forefront of advancements in the understanding of genetic disorders, particularly Huntington's disease, a central focus of its efforts. The HDF's mission encompasses supporting innovative research, fostering collaborations among scientists, and promoting the sharing of knowledge within the field of genetic and neurodegenerative diseases.

History

The Hereditary Disease Foundation was established by Dr. Milton Wexler, a psychoanalyst, after his wife was diagnosed with Huntington's disease, a hereditary neurodegenerative disorder. Dr. Wexler's personal connection to the disease motivated him to create a foundation that could spearhead the search for a cure. Over the years, the HDF has played a pivotal role in key genetic discoveries, including the identification of the gene responsible for Huntington's disease in 1993. This breakthrough was part of the foundation's broader initiative, the Venezuela Project, which involved studying large families in Venezuela with a high incidence of Huntington's disease to locate the gene that causes the condition.

Research and Initiatives

The Hereditary Disease Foundation focuses on supporting innovative research that can lead to the understanding and treatment of genetic diseases. Its initiatives include:

- **The Venezuela Project**: A landmark study that led to the identification of the gene responsible for Huntington's disease. - **Cure HD Initiative**: Aims to fund research that leads directly to treatments and cures for Huntington's disease. - **Grants and Fellowships**: The HDF provides funding to researchers through grants and fellowships to encourage young scientists and support pioneering research projects.

Impact

The work of the Hereditary Disease Foundation has had a significant impact on the field of genetic research. By focusing on collaborative efforts and the funding of cutting-edge research, the HDF has contributed to major scientific discoveries, including the mapping of the Huntington's disease gene. These advancements have not only deepened the understanding of genetic diseases but have also paved the way for the development of therapeutic strategies and treatments.

Future Directions

The Hereditary Disease Foundation continues to support research with the potential to uncover treatments and cures for genetic diseases. With advances in genetic engineering, gene therapy, and other biomedical technologies, the HDF remains committed to its mission of eradicating genetic diseases. The foundation also emphasizes the importance of ethical considerations in genetic research, advocating for responsible scientific practices that respect the dignity and rights of individuals affected by genetic disorders.

See Also

• Genetic Disorders
• Huntington's Disease
• Gene Therapy
• Neurodegenerative Diseases