Histone H2B type 1-C

Protein HIST1H2BC PDB 1aoi

Histone H2B type 1-C is a protein that in humans is encoded by the HIST1H2BC gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.

Structure

The protein encoded by this gene is a member of the histone family. Histone H2B type 1-C is a core component of the nucleosome structure and plays a crucial role in chromatin compaction and gene regulation.

Clinical Significance

Mutations in histone genes have been associated with various diseases, including cancer and developmental disorders. Understanding the function and regulation of histone proteins like Histone H2B type 1-C is important for unraveling the molecular mechanisms underlying these diseases.

References

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