Histopathologic diagnosis of prostate cancer
Histopathologic Diagnosis of Prostate Cancer[edit | edit source]
The histopathologic diagnosis of prostate cancer is a critical component in the management and treatment of the disease. It involves the examination of prostate tissue under a microscope to identify cancerous cells and determine the type and aggressiveness of the cancer.
Tissue Sampling[edit | edit source]
The first step in the histopathologic diagnosis is obtaining a tissue sample from the prostate. This is typically done through a prostate biopsy, where multiple core samples are taken from different areas of the prostate gland. The samples are then processed and prepared for microscopic examination.
Microscopic Examination[edit | edit source]
The microscopic examination of prostate tissue involves identifying the presence of cancerous cells and determining the Gleason score, which is a grading system used to evaluate the aggressiveness of prostate cancer.
Gleason Grading System[edit | edit source]
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The Gleason score is based on the architectural pattern of the cancerous tissue. It ranges from 6 to 10, with higher scores indicating more aggressive cancer. The score is determined by adding the two most predominant patterns observed in the tissue sample.
Types of Prostate Cancer[edit | edit source]
Prostate cancer can be classified into several types based on the histopathologic features:
Acinar Adenocarcinoma[edit | edit source]
This is the most common type of prostate cancer, characterized by small glandular structures.
Ductal Adenocarcinoma[edit | edit source]
Ductal adenocarcinoma is a less common variant that tends to be more aggressive and is characterized by large glandular structures.
Intraductal Carcinoma[edit | edit source]
Intraductal carcinoma is characterized by cancerous cells within the ducts of the prostate and is often associated with high-grade cancer.
Urothelial Carcinoma[edit | edit source]
Urothelial carcinoma can occur in the prostatic urethra and is distinct from the more common adenocarcinomas of the prostate.
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