Homeotic gene

Homeotic genes are a group of genes that control the development of the body plan of an organism. They are responsible for determining the identity of body segments. In many organisms, homeotic genes are organized into clusters known as Hox genes.

Function

Homeotic genes encode transcription factors that control the expression of genes responsible for the development of specific body segments. They do this by binding to specific DNA sequences and regulating the transcription of target genes. The proteins encoded by homeotic genes contain a DNA-binding domain known as the homeodomain.

Discovery

Homeotic genes were first discovered in the fruit fly Drosophila melanogaster. Mutations in these genes resulted in dramatic transformations of body parts, such as the formation of legs where antennae should be. This led to the realization that these genes play a crucial role in determining the identity of body segments.

Hox genes

In many organisms, homeotic genes are organized into clusters known as Hox genes. These genes are found in a specific order on the chromosome that corresponds to the order of the body segments they control. This phenomenon, known as colinearity, is a key feature of Hox genes.

Evolution

Homeotic genes are highly conserved across different species, suggesting that they play a crucial role in the evolution of body plans. Changes in the expression or function of these genes can lead to major changes in body plan, and may have contributed to the evolution of new body forms.

See also

• Hox gene
• Homeobox
• Morphogenesis
• Developmental biology

References

Homeotic gene Resources
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