Hoof wall separation disease

Hoof Wall Separation Disease (HWSD) is a genetic disorder that affects the hooves of horses. It is characterized by a separation between the outer hoof wall and the underlying dermal tissue. This separation can lead to lameness and other complications. HWSD is caused by a mutation in the SERPINB11 gene.

Symptoms

The primary symptom of HWSD is a separation of the hoof wall. This can be seen as a horizontal crack or split in the hoof wall, usually starting at the toe and progressing towards the heel. Other symptoms may include lameness, pain, and difficulty walking.

Causes

HWSD is caused by a mutation in the SERPINB11 gene. This gene is responsible for producing a protein that is involved in the formation of the hoof wall. When this gene is mutated, it results in a defective protein that cannot properly form the hoof wall, leading to separation.

Diagnosis

Diagnosis of HWSD is typically made through a combination of clinical signs and genetic testing. A veterinarian may suspect HWSD based on the appearance of the horse's hooves and symptoms such as lameness. Genetic testing can confirm the diagnosis.

Treatment

There is currently no cure for HWSD. Treatment is focused on managing symptoms and preventing complications. This may include regular hoof care, pain management, and in some cases, corrective shoeing.

Prevention

As HWSD is a genetic disorder, prevention is focused on responsible breeding practices. Horses with the SERPINB11 mutation should not be bred, as they can pass the mutation on to their offspring.

See also

• Horse health
• Genetic disorders in horses
• Hoof care

References

Hoof wall separation disease Resources
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