Humanized

Humanized refers to a process in which non-human substances are modified to be similar to human substances. This term is often used in the context of antibodies and proteins, where non-human antibodies or proteins are modified to resemble human antibodies or proteins to reduce the risk of an immune response.

Overview

Humanization is a critical process in the development of therapeutic antibodies and proteins. It involves the modification of non-human antibodies or proteins, such as those from mice, to resemble human antibodies or proteins. This is done to reduce the risk of an immune response when these substances are used in humans.

Process

The process of humanization involves several steps. First, the non-human antibody or protein is identified and its structure is determined. Then, the parts of the antibody or protein that are likely to cause an immune response in humans are identified. These parts are then replaced with human equivalents, creating a 'humanized' antibody or protein.

Applications

Humanized antibodies and proteins have a wide range of applications in medicine. They are used in the treatment of a variety of diseases, including cancer, autoimmune diseases, and infectious diseases. They are also used in diagnostic tests and research.

See also

• Antibody
• Protein
• Therapeutic
• Cancer
• Autoimmune diseases
• Infectious diseases
• Diagnostic tests
• Research

References

Humanized Resources
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