Huwentoxin
Huwentoxin is a toxin derived from the venom of the Chinese bird spider Haplopelma schmidti. It is a neurotoxin that affects the nervous system by blocking voltage-gated sodium channels.
Structure[edit | edit source]
Huwentoxin is a small protein composed of 33 amino acids. It has a compact structure stabilized by three disulfide bridges. The structure of huwentoxin is similar to other spider toxins, such as omega-agatoxin and mu-agatoxin.
Function[edit | edit source]
Huwentoxin acts on the nervous system by blocking voltage-gated sodium channels. These channels are essential for the propagation of action potentials in neurons. By blocking these channels, huwentoxin prevents the transmission of nerve signals, leading to paralysis.
Medical uses[edit | edit source]
Research is being conducted into the potential use of huwentoxin as a therapeutic agent. Due to its ability to block sodium channels, it could be used to treat conditions such as chronic pain, epilepsy, and cardiac arrhythmias. However, further research is needed to determine the safety and efficacy of huwentoxin in these applications.
See also[edit | edit source]
| Huwentoxin Resources | |
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References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
