IBZM
IBZM (Iodobenzamide) is a radioligand used in nuclear medicine and neuroimaging to visualize and study the dopamine receptor D2/D3 in the brain. It is a non-invasive method that allows for the in vivo examination of the dopaminergic system.
History[edit | edit source]
IBZM was first synthesized in the 1980s as a tool for the study of the dopaminergic system. It was developed as a radiotracer for Single-photon emission computed tomography (SPECT) imaging.
Mechanism of Action[edit | edit source]
IBZM binds selectively to the D2/D3 dopamine receptors in the brain. It is a competitive antagonist, meaning it competes with dopamine for the same binding site. This allows for the visualization of the distribution and density of these receptors in the brain.
Applications[edit | edit source]
IBZM SPECT is used in the diagnosis and monitoring of various neurological disorders, including Parkinson's disease, schizophrenia, and drug addiction. It can also be used in research to study the effects of drugs on the dopaminergic system.
Procedure[edit | edit source]
The procedure for an IBZM SPECT scan involves the intravenous injection of the radioligand, followed by a waiting period to allow for the radioligand to distribute in the brain. The patient is then placed in the SPECT scanner, and images are taken over a period of time.
Safety and Side Effects[edit | edit source]
As with any medical procedure, there are potential risks and side effects associated with IBZM SPECT. These can include allergic reactions to the radioligand, as well as the potential for radiation exposure. However, the benefits of the procedure generally outweigh these risks.
See Also[edit | edit source]
 | This Nuclear medicine article is a stub. You can help WikiMD by expanding it. |
 | This neuroimaging article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
