ICAM4

ICAM4 (InterCellular Adhesion Molecule 4), also known as LW blood group antigen or Landsteiner-Wiener blood group antigen, is a protein that in humans is encoded by the ICAM4 gene. It is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Function[edit | edit source]

The ICAM4 protein interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) that is a receptor for fibronectin. The interaction of ICAM4 with ITGA4/ITGB1 enhances the adhesion of lymphocytes, including peripheral blood memory T cells, to vascular endothelium. Distribution of ICAM4 on melanoma cells and exosomes regulates NK cell trafficking in liver metastasis.

Clinical significance[edit | edit source]

Mutations in the ICAM4 gene are associated with the LW blood group system. The system consists of two antigens, LWa and LWb. Anti-LWa and anti-LWb are naturally occurring antibodies found in the plasma of individuals lacking the corresponding antigens.

References[edit | edit source]

External links[edit | edit source]

GeneCards: ICAM4

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