ICP8

ICP8 (Infected Cell Protein 8) is a protein that is encoded by the Herpes simplex virus (HSV). It is a single-stranded DNA binding protein that is essential for DNA replication in the virus. ICP8 is also involved in the recombination of viral DNA.

Function

ICP8 has several functions in the life cycle of the HSV. It is involved in the replication, recombination, and repair of the viral DNA. It also plays a role in the formation of replication compartments within the infected cell, where viral DNA replication takes place.

Structure

ICP8 is a large protein, with a molecular weight of approximately 140 kDa. It is composed of a single polypeptide chain, and has a highly conserved N-terminal domain that is responsible for its DNA binding activity. The C-terminal domain of ICP8 is less conserved, and is thought to be involved in protein-protein interactions.

Role in Disease

As a key player in the replication of the HSV, ICP8 is a potential target for antiviral drugs. Inhibition of ICP8 could prevent the virus from replicating, thereby stopping the infection. However, more research is needed to fully understand the function of ICP8 and its potential as a drug target.

See Also

• Herpes simplex virus
• DNA replication
• Protein

References

ICP8 Resources
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