ID3 (gene)

ID3 (gene)

The ID3 (gene) or Inhibitor of DNA Binding 3 is a gene that encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix (bHLH) transcription factors which can form heterodimers with other bHLH proteins. The encoded protein is believed to play a role in cell cycle progression by inhibiting the cellular differentiation process.

File:ID3 gene location on human chromosome 1.png

Location of ID3 gene on human chromosome 1

Function

The ID3 gene is a member of the ID family, which includes four different proteins: ID1, ID2, ID3, and ID4. These proteins are involved in various cellular processes, including cell proliferation, cell differentiation, and apoptosis. They function by binding to other bHLH transcription factors, preventing them from binding to DNA and activating gene expression. This inhibitory action is critical for the control of cell growth and differentiation.

Clinical significance

Mutations in the ID3 gene have been associated with several types of cancer, including leukemia, lymphoma, and glioblastoma. These mutations often result in the overexpression of the ID3 protein, leading to uncontrolled cell growth and proliferation. In addition, ID3 has been implicated in the development of cardiovascular disease, as it plays a role in the regulation of vascular smooth muscle cell proliferation and differentiation.

See also

• Inhibitor of DNA binding
• Helix-loop-helix
• Transcription factor
• Cell cycle
• Cell differentiation