ID3 (gene)

ID3 (Inhibitor of DNA Binding 3) is a protein that in humans is encoded by the ID3 gene. The ID3 gene is a member of the ID gene family, which is involved in the regulation of cell growth, differentiation, and development.

Function

The ID3 protein is a member of the helix-loop-helix (HLH) family of transcription factors. It acts as a dominant negative regulator of basic HLH transcription factors by forming non-functional heterodimers. This prevents the binding of these transcription factors to E-box sequences in the DNA, thereby inhibiting their ability to regulate gene expression.

ID3 plays a crucial role in various biological processes, including neurogenesis, angiogenesis, and the immune response. It is also involved in the regulation of the cell cycle and can influence cell proliferation and apoptosis.

Clinical Significance

Alterations in the expression of ID3 have been associated with several types of cancer, including breast cancer, prostate cancer, and lymphoma. Overexpression of ID3 can lead to increased cell proliferation and tumorigenesis, while loss of ID3 function can result in impaired cell growth and differentiation.

Research has shown that ID3 may play a role in the development of cardiovascular disease and metabolic disorders. It is also being studied as a potential target for therapeutic intervention in various diseases.

Interactions

ID3 interacts with several other proteins, including members of the E protein family, such as E2A, HEB, and E2-2. These interactions are important for the regulation of gene expression and the maintenance of cellular homeostasis.

See Also

• ID1 (gene)
• ID2 (gene)
• ID4 (gene)

External Links

• ID3 Gene - NCBI
• ID3 Protein - UniProt