IKZF3

IKZF3 (also known as Aiolos) is a gene that encodes a protein in humans. This protein is a member of the Ikaros family of zinc-finger proteins. It plays a crucial role in the regulation of lymphocyte development.

Function

The IKZF3 protein is a transcription factor that plays a key role in the development and function of B cells and T cells. It is involved in the regulation of gene expression and cell differentiation, and it also plays a role in the immune response.

Structure

The IKZF3 gene is located on the short (p) arm of chromosome 17 at position 13.2. The protein encoded by this gene contains six C2H2-type zinc fingers, which are involved in DNA binding.

Clinical significance

Mutations in the IKZF3 gene have been associated with various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis. In addition, IKZF3 has been implicated in certain types of cancer, including leukemia and lymphoma.

Research

Research is ongoing to better understand the role of IKZF3 in health and disease. This includes studies to identify potential therapeutic targets for diseases associated with mutations in the IKZF3 gene.

File:IKZF3 gene location on human chromosome 17.png

Location of the IKZF3 gene on human chromosome 17.

See also

• Ikaros family
• Zinc finger protein
• Transcription factor
• Autoimmune disease
• Cancer