IL18BP
IL18BP is a protein that in humans is encoded by the IL18BP gene. It is a naturally occurring inhibitor of the proinflammatory cytokine IL18. IL18BP forms a complex with IL18, thus preventing the latter from binding to its receptor and mediating inflammatory responses.
Function[edit | edit source]
The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. The encoded protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells.
Clinical significance[edit | edit source]
Alterations in the balance between IL18 and IL18BP are associated with diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis.
Interactions[edit | edit source]
IL18BP has been shown to interact with IL18.
References[edit | edit source]
External links[edit | edit source]
- IL18BP at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
