IRF3
IRF3 or Interferon Regulatory Factor 3 is a protein that in humans is encoded by the IRF3 gene. It is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. It is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.
Function[edit | edit source]
IRF3 is a key transcription factor involved in the induction of interferon (IFN) in response to viral infection. It is activated by a variety of viruses, including herpes simplex virus, vesicular stomatitis virus, and Sendai virus. Upon activation, IRF3 translocates to the nucleus and binds to the IFN-stimulated response element (ISRE) in the promoter of IFN genes, leading to the production of IFN and the activation of IFN-stimulated genes.
Clinical significance[edit | edit source]
Mutations in the IRF3 gene have been associated with susceptibility to herpes simplex encephalitis, a rare complication of herpes simplex virus infection. Additionally, IRF3 has been implicated in the immune response to SARS-CoV-2, the virus that causes COVID-19. Studies have shown that SARS-CoV-2 can inhibit the activation of IRF3, thereby suppressing the production of IFN and evading the immune response.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- IRF3 at the National Center for Biotechnology Information
IRF3 Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD