IRF5

IRF5 or Interferon Regulatory Factor 5 is a protein that in humans is encoded by the IRF5 gene. It is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity.

Function

IRF5 is a member of the interferon regulatory factors (IRFs) family, proteins known for regulating the transcription of interferon (IFN) alpha and beta. Interferons are produced in response to viral infection, and in turn activate the immune cells that suppress virus replication. IRF5 has been further associated with apoptosis and cell growth regulation, adding to its role in the immune response.

Clinical significance

Mutations in the IRF5 gene can lead to decreased production of interferon, which can result in an increased susceptibility to viral infections. Additionally, polymorphisms in this gene are associated with an increased risk of systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA).

See also

• Interferon regulatory factors
• Interferon
• Systemic lupus erythematosus
• Rheumatoid arthritis

External links

• IRF5 at the US National Library of Medicine Medical Subject Headings (MeSH)

IRF5 Resources
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