IRX4

IRX4 is a gene that encodes a member of the Iroquois homeobox gene family in humans. Members of this family are involved in pattern formation and cell differentiation during embryogenesis. The encoded protein has been associated with cardiac development, specifically the formation of the ventricular chambers.

Function

The IRX4 gene is part of the Iroquois homeobox gene family, which plays a crucial role in the early stages of embryogenesis. This gene family is involved in the regulation of pattern formation and cell differentiation. The IRX4 gene, in particular, is associated with the development of the heart, specifically the formation of the ventricular chambers. It is expressed in the ventricular myocardium and is thought to play a key role in the establishment of the ventricular identity.

Clinical Significance

Mutations in the IRX4 gene have been associated with various cardiac diseases. For instance, a study found that a mutation in this gene was linked to ventricular septal defect, a common form of congenital heart disease. Additionally, variations in the IRX4 gene have been associated with an increased risk of atrial fibrillation, the most common type of irregular heartbeat.

Research

Research into the IRX4 gene is ongoing, with scientists aiming to better understand its role in heart development and disease. This could potentially lead to new treatments for cardiac conditions and a better understanding of congenital heart defects.

File:IRX4 gene location on human chromosome 5.png

Location of the IRX4 gene on human chromosome 5

See Also

• Iroquois homeobox gene family
• Cardiac development
• Ventricular septal defect
• Atrial fibrillation