ISCA1

Ideogram human chromosome 9

ISCA1 ISCA1, also known as Iron-Sulfur Cluster Assembly 1, is a protein involved in the biogenesis of iron-sulfur clusters in cells. Iron-sulfur clusters are essential cofactors found in a variety of proteins that play crucial roles in various cellular processes such as electron transfer, enzymatic catalysis, and regulation of gene expression. Function ISCA1 is a key player in the assembly and transfer of iron and sulfur atoms to form these clusters. It interacts with other proteins and enzymes to facilitate the incorporation of iron and sulfur into target proteins. This process is essential for the proper functioning of many cellular pathways. Role in Cellular Processes Iron-sulfur clusters are integral components of several important enzymes involved in processes like respiration, DNA repair, and nitrogen fixation. ISCA1's role in iron-sulfur cluster biogenesis is crucial for the proper functioning of these enzymes and, consequently, for the overall health and viability of the cell. Genetic Mutations Mutations in the gene encoding ISCA1 can lead to defects in iron-sulfur cluster assembly, resulting in various disorders known as iron-sulfur cluster biogenesis disorders. These disorders can manifest as mitochondrial dysfunction, neurodegeneration, and other severe health issues. Research and Implications Understanding the function of ISCA1 and its role in iron-sulfur cluster assembly is of great interest to researchers studying cellular metabolism, mitochondrial function, and genetic diseases. Insights gained from studying ISCA1 may lead to the development of novel therapeutic strategies for treating disorders associated with iron-sulfur cluster deficiencies. References - Iron-sulfur cluster - Protein biogenesis