ITGB3

ITGB3 (Integrin Subunit Beta 3) is a protein that in humans is encoded by the ITGB3 gene. This protein is part of the integrin family and is involved in various cellular processes such as cell adhesion and recognition in processes like hemostasis, thrombosis, wound healing, immune response and metastasis.

Function[edit | edit source]

The ITGB3 protein is a part of the integrin alpha-IIb/beta-3 complex. This complex is located on the surface of platelets and is involved in the process of platelet aggregation and also in the formation of blood clots. The alpha-IIb/beta-3 complex binds to fibrinogen, an important protein that is involved in the clotting of blood. This binding leads to the activation of the ITGB3 protein, which then interacts with other proteins to initiate the clotting process.

Clinical significance[edit | edit source]

Mutations in the ITGB3 gene can lead to diseases such as Glanzmann's thrombasthenia, which is a rare bleeding disorder, and the Platelet type- Von Willebrand disease, which is a condition characterized by prolonged bleeding time, abnormal platelet aggregation, and a reduced amount of von Willebrand factor.

References[edit | edit source]

External links[edit | edit source]

ITGB3 at the National Center for Biotechnology Information

ITGB3 Resources
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