ITIH4

Ideogram human chromosome 3

ITIH4

Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) is a protein that in humans is encoded by the ITIH4 gene. ITIH4 is a heavy chain of the inter-alpha-trypsin inhibitor (ITI) family, which plays a crucial role in extracellular matrix stabilization and inflammation regulation.

Structure

ITIH4 is composed of multiple domains, including a chondroitin sulfate chain attachment site, a von Willebrand factor type A domain, and a C-terminal domain. The protein undergoes post-translational modifications, such as glycosylation and sulfation, which are essential for its function.

Function

ITIH4 is involved in various biological processes, including wound healing, tissue repair, and immune response modulation. It acts as a carrier protein for hyaluronan and contributes to the maintenance of tissue integrity. Additionally, ITIH4 has been implicated in the pathogenesis of certain diseases, such as cancer and inflammatory disorders.

Clinical Significance

Abnormal levels of ITIH4 have been associated with several medical conditions, making it a potential biomarker for disease diagnosis and prognosis. Studies have shown that ITIH4 expression is altered in cancer patients, suggesting its potential utility as a diagnostic marker in oncology.

Interactions

ITIH4 interacts with other proteins within the extracellular matrix, such as hyaluronan and various proteases. These interactions are crucial for the proper functioning of ITIH4 in maintaining tissue homeostasis and regulating inflammatory responses.