Ileal sodium/bile acid cotransporter
The ileal sodium/bile acid cotransporter (ISBAT), also known as the apical sodium-dependent bile acid transporter (ASBT), is a protein that in humans is encoded by the SLC10A2 gene. This transporter is primarily expressed in the ileum, the final section of the small intestine.
Function[edit | edit source]
The ileal sodium/bile acid cotransporter plays a crucial role in the enterohepatic circulation of bile acids. It is responsible for the reabsorption of bile acids from the intestinal lumen into the enterocytes of the ileum. This process is sodium-dependent, meaning that the transport of bile acids is coupled with the transport of sodium ions.
Clinical significance[edit | edit source]
Mutations in the SLC10A2 gene can lead to primary bile acid malabsorption, a condition characterized by chronic diarrhea and a reduced ability to absorb bile acids. This can result in bile acid diarrhea and fat malabsorption.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
