Immunoglobulin e
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) that has only been found in mammals. It plays an essential role in the body's immune system. IgE has been associated with various allergic diseases including asthma, allergic rhinitis, and atopic dermatitis.
Structure[edit | edit source]
IgE's main function is immunity to parasites such as parasitic worms like Schistosoma spp, Trichinella spiralis, and Fasciola hepatica. IgE may also be important during immune defense against certain protozoan parasites such as Plasmodium falciparum.
Function[edit | edit source]
IgE also plays a pivotal role in responses to allergens, such as: food, pollen, and medications. Functions of IgE include antigen recognition and binding, regulation of immune response, and prevention of disease by attacking invading pathogens.
Clinical significance[edit | edit source]
High IgE levels can be a result of a parasitic infection or can be associated with different types of tumors. IgE also plays a significant role in allergic reactions. In allergic individuals, an allergen induces the production of IgE antibodies that can bind to Mast cells and basophils in the body.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
