Indacaterol/glycopyrronium bromide/mometasone
Indacaterol/glycopyrronium bromide/mometasone
Indacaterol/glycopyrronium bromide/mometasone is a combination medication used in the management of chronic obstructive pulmonary disease (COPD) and asthma. This combination includes three active ingredients: indacaterol, glycopyrronium bromide, and mometasone furoate, each contributing to the therapeutic effects of the medication.
Pharmacology[edit | edit source]
Indacaterol[edit | edit source]
Indacaterol is a long-acting beta-2 adrenergic agonist (LABA). It works by stimulating beta-2 adrenergic receptors in the bronchial smooth muscle, leading to bronchodilation. This helps to relieve symptoms such as shortness of breath and wheezing in patients with COPD and asthma.
Glycopyrronium Bromide[edit | edit source]
Glycopyrronium bromide is a long-acting muscarinic antagonist (LAMA). It blocks the action of acetylcholine on muscarinic receptors in the airway smooth muscle, resulting in bronchodilation. This action complements the effects of indacaterol, providing a more comprehensive bronchodilatory effect.
Mometasone Furoate[edit | edit source]
Mometasone furoate is a corticosteroid with anti-inflammatory properties. It reduces inflammation in the airways, decreasing the frequency and severity of asthma attacks and COPD exacerbations. Mometasone works by inhibiting multiple inflammatory cytokines and mediators.
Indications[edit | edit source]
Indacaterol/glycopyrronium bromide/mometasone is indicated for the maintenance treatment of patients with COPD and asthma who require a combination of a LABA, a LAMA, and an inhaled corticosteroid (ICS) to manage their symptoms and reduce the risk of exacerbations.
Administration[edit | edit source]
The medication is typically administered via inhalation using a dry powder inhaler. Patients are advised to use the inhaler as prescribed by their healthcare provider, usually once daily.
Side Effects[edit | edit source]
Common side effects of indacaterol/glycopyrronium bromide/mometasone may include:
- Headache
- Nasopharyngitis
- Cough
- Oropharyngeal pain
Serious side effects can include:
- Paradoxical bronchospasm
- Hypersensitivity reactions
- Cardiovascular effects such as palpitations and tachycardia
Contraindications[edit | edit source]
This combination medication is contraindicated in patients with a known hypersensitivity to any of its components. It should be used with caution in patients with cardiovascular disorders, glaucoma, urinary retention, and other conditions that may be exacerbated by the medication's effects.
Also see[edit | edit source]
- Chronic obstructive pulmonary disease
- Asthma
- Beta-2 adrenergic agonist
- Muscarinic antagonist
- Corticosteroid
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