Indecainide
Indecainide is a Class Ic antiarrhythmic agent that was primarily used in the treatment of cardiac arrhythmia. It is no longer in use due to its potential for proarrhythmia, a condition where the drug exacerbates or causes new arrhythmias.
Etymology[edit | edit source]
The term "Indecainide" is derived from the chemical structure of the compound, which includes an indene ring and a cainide group. The prefix "inde-" comes from the Latin word "indicus", meaning "Indian", referring to the indigo plant from which indene was first derived. The suffix "-cainide" is a common ending for local anesthetics and antiarrhythmic agents, derived from the prototype drug in this class, procainamide.
Pharmacology[edit | edit source]
Indecainide works by blocking the fast inward sodium current, thereby slowing the rate of rise of the action potential and prolonging the refractory period. This results in a decrease in the conduction velocity of the heart, which can help to control arrhythmias.
Clinical Use[edit | edit source]
Indecainide was primarily used to treat ventricular tachycardia, a type of rapid heart rhythm originating from the lower chambers of the heart. However, it was found to have a high incidence of proarrhythmia, particularly in patients with structural heart disease. As a result, it is no longer in clinical use.
Related Terms[edit | edit source]
See Also[edit | edit source]
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