Indospicine

Indospicine is a non-proteinogenic amino acid that is found in the plant Indigofera spicata, also known as creeping indigo. It is toxic to some animals, including dogs, and has been implicated in cases of hepatotoxicity and neurotoxicity.

History

Indospicine was first identified in the 1960s in Australia, where it was found to cause liver damage in livestock that had consumed Indigofera spicata. The compound was named after the plant in which it was discovered.

Structure and properties

Indospicine is a guanidino compound that is structurally similar to the amino acid arginine. It is a non-proteinogenic amino acid, meaning it is not used in the biosynthesis of proteins.

Toxicity

Indospicine is toxic to some animals, including dogs, and has been implicated in cases of hepatotoxicity and neurotoxicity. The mechanism of toxicity is not fully understood, but it is thought to involve the inhibition of arginase, an enzyme involved in the urea cycle.

Treatment and prevention

There is currently no specific antidote for indospicine poisoning. Treatment is supportive and may include fluid therapy and liver support. Prevention involves avoiding consumption of Indigofera spicata and other plants that contain indospicine.

See also

• Non-proteinogenic amino acids
• Hepatotoxicity
• Neurotoxicity

Indospicine Resources
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