Integrin alphaXbeta2

Integrin alphaXbeta2 is a protein that in humans is encoded by the ITGAX and ITGB2 genes. It is also known as CD11c/CD18 and complement receptor 4 (CR4). The protein encoded by this gene belongs to the integrin alpha chain family of proteins.

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.

Function

The Integrin alpha X beta 2 is a receptor for fibrinogen, factor X and ICAM1. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Clinical significance

Defects in the ITGAX are a cause of leukocyte adhesion deficiency type I (LAD1). Leukocyte adhesion deficiency is an autosomal recessive disorder characterized by recurrent bacterial infections, impaired pus formation and wound healing, delayed separation of the umbilical cord, and leukocytosis.

See also

• Integrin
• Cluster of Differentiation
• Leukocyte adhesion deficiency

External links

• Integrin alphaXbeta2 at WikiMD

Integrin alphaXbeta2 Resources
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