CRSP3

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Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene.[1][2]

Function[edit | edit source]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]

Interactions[edit | edit source]

CRSP3 has been shown to interact with Estrogen receptor alpha,[3] CEBPB[4] and Cyclin-dependent kinase 8.[3][5]

References[edit | edit source]

  1. ↑ , The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1, Nature, Vol. 397(Issue: 6718), pp. 446–50, DOI: 10.1038/17141, PMID: 9989412,
  2. ↑ 2.0 2.1 Entrez Gene: CRSP3 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa Full text, ,
  3. ↑ 3.0 3.1 , The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro, Proceedings of the National Academy of Sciences of the United States of America, Vol. 99(Issue: 5), pp. 2642–7, DOI: 10.1073/pnas.261715899, PMID: 11867769, PMC: 122401,
  4. ↑ , Ras induces mediator complex exchange on C/EBP beta, Molecular Cell, Vol. 13(Issue: 2), pp. 241–50, DOI: 10.1016/S1097-2765(03)00521-5, PMID: 14759369,
  5. ↑ , Characterization of mediator complexes from HeLa cell nuclear extract, Molecular and Cellular Biology, Vol. 21(Issue: 14), pp. 4604–13, DOI: 10.1128/MCB.21.14.4604-4613.2001, PMID: 11416138, PMC: 87123,


External links[edit | edit source]

Further reading[edit | edit source]

, 

 Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex, 
 Nature, 
  
 Vol. 398(Issue: 6730), 
 pp. 824–8, 
 DOI: 10.1038/19783, 
 PMID: 10235266,

, 

 Composite co-activator ARC mediates chromatin-directed transcriptional activation, 
 Nature, 
  
 Vol. 398(Issue: 6730), 
 pp. 828–32, 
 DOI: 10.1038/19789, 
 PMID: 10235267,

, 

 Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein, 
 Nature, 
  
 Vol. 399(Issue: 6733), 
 pp. 276–9, 
 DOI: 10.1038/20466, 
 PMID: 10353252,

, 

 Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro, 
 DNA Research, 
  
 Vol. 6(Issue: 5), 
 pp. 337–45, 
 DOI: 10.1093/dnares/6.5.337, 
 PMID: 10574462,

, 

 Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator, 
 Proceedings of the National Academy of Sciences of the United States of America, 
  
 Vol. 97(Issue: 11), 
 pp. 6212–7, 
 DOI: 10.1073/pnas.97.11.6212, 
 PMID: 10823961, 
 PMC: 18584,

, 

 DNA cloning using in vitro site-specific recombination, 
 Genome Research, 
  
 Vol. 10(Issue: 11), 
 pp. 1788–95, 
 DOI: 10.1101/gr.143000, 
 PMID: 11076863, 
 PMC: 310948,

, 

 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs, 
 Genome Research, 
  
 Vol. 11(Issue: 3), 
 pp. 422–35, 
 DOI: 10.1101/gr.GR1547R, 
 PMID: 11230166, 
 PMC: 311072,

, 

 Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit, 
 Science, 
  
 Vol. 296(Issue: 5568), 
 pp. 755–8, 
 DOI: 10.1126/science.1068943, 
 PMID: 11934987,

, 

 External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator, 
 Proceedings of the National Academy of Sciences of the United States of America, 
  
 Vol. 99(Issue: 20), 
 pp. 12747–52, 
 DOI: 10.1073/pnas.202162199, 
 PMID: 12242338, 
 PMC: 130531,

, 

 Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs, 
 Genome Research, 
  
 Vol. 12(Issue: 11), 
 pp. 1773–84, 
 DOI: 10.1101/gr.406902, 
 PMID: 12421765, 
 PMC: 187542,

, 

 Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP, 
 Cancer Research, 
  
 Vol. 63(Issue: 2), 
 pp. 432–40, 
  
 PMID: 12543799,

, 

 A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex, 
 The Journal of Biological Chemistry, 
  
 Vol. 278(Issue: 50), 
 pp. 49671–4, 
 DOI: 10.1074/jbc.C300444200, 
 PMID: 14576168,

, 

 A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2, 
 The Journal of Biological Chemistry, 
  
 Vol. 279(Issue: 7), 
 pp. 5846–51, 
 DOI: 10.1074/jbc.M312523200, 
 PMID: 14638676,

, 

 Ras induces mediator complex exchange on C/EBP beta, 
 Molecular Cell, 
  
 Vol. 13(Issue: 2), 
 pp. 241–50, 
 DOI: 10.1016/S1097-2765(03)00521-5, 
 PMID: 14759369,

, 

 A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology, 
 Molecular Cell, 
  
 Vol. 14(Issue: 5), 
 pp. 685–91, 
 DOI: 10.1016/j.molcel.2004.05.006, 
 PMID: 15175163,

, 

 BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220, 
 Oncogene, 
  
 Vol. 23(Issue: 35), 
 pp. 6000–5, 
 DOI: 10.1038/sj.onc.1207786, 
 PMID: 15208681,

, 

 From ORFeome to biology: a functional genomics pipeline, 
 Genome Research, 
  
 Vol. 14(Issue: 10B), 
 pp. 2136–44, 
 DOI: 10.1101/gr.2576704, 
 PMID: 15489336, 
 PMC: 528930,


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Contributors: Prab R. Tumpati, MD