Intercellular cleft

Intercellular cleft is a term used in Anatomy and Cell biology to describe the small gaps or spaces that exist between adjacent cells in a tissue. These clefts play a crucial role in the exchange of substances between cells and their environment.

Structure

Intercellular clefts are typically narrow, irregular spaces that separate the plasma membranes of neighboring cells. They are formed due to the irregular arrangement of the lipid bilayer of the plasma membrane. The size and shape of these clefts can vary depending on the type of tissue and the specific cells involved.

Function

The primary function of intercellular clefts is to facilitate the exchange of substances between cells and their surrounding environment. This includes the transport of nutrients, waste products, and signaling molecules. In some tissues, such as the endothelium of blood vessels, intercellular clefts also play a role in the movement of fluid and cells across the tissue barrier.

Clinical significance

Abnormalities in the structure or function of intercellular clefts can contribute to various pathological conditions. For example, in certain types of cancer, changes in the intercellular clefts can facilitate the spread of cancer cells. Similarly, in conditions such as edema, increased permeability of the intercellular clefts can lead to excessive fluid accumulation in the tissues.

See also

• Gap junction
• Tight junction
• Desmosome