Interleukin-20

Interleukin-20 (IL-20) is a protein that in humans is encoded by the IL20 gene. It is a member of the interleukin family, a group of cytokines that play a central role in the regulation of the immune system.

Function

Interleukin-20 is a cytokine that has been shown to act as a regulator of keratinocyte proliferation and differentiation. It also can stimulate the production of matrix metalloproteinases and other inflammatory mediators from synovial fibroblasts, leading to cartilage destruction and bone erosion in rheumatoid arthritis.

Structure

The IL-20 protein is a member of the IL-10 family of cytokines. It is a single-chain protein, composed of 176 amino acids, with a molecular weight of approximately 20 kDa.

Clinical significance

Interleukin-20 has been implicated in several autoimmune diseases, including psoriasis, rheumatoid arthritis, and atherosclerosis. It is also involved in the immune response to infections.

Research

Research is ongoing to develop drugs that can block the action of IL-20, with the aim of treating autoimmune diseases and preventing tissue damage in chronic inflammatory conditions.

See also

• Interleukin 10
• Cytokine
• Autoimmune disease
• Rheumatoid arthritis
• Psoriasis