Interleukin 20

Interleukin 20 (IL-20) is a protein that in humans is encoded by the IL20 gene. It is a member of the interleukin family, a group of signaling molecules that are involved in the immune system's response to disease and injury.

Function

IL-20 is a cytokine that is involved in inflammation and immune responses. It is produced by keratinocytes and acts on epithelial cells, keratinocytes, and fibroblasts to stimulate cell proliferation and differentiation. This cytokine can also induce angiogenesis and the production of a variety of inflammatory chemokines.

Clinical significance

IL-20 has been implicated in a variety of diseases, including psoriasis, rheumatoid arthritis, and atherosclerosis. It is thought to play a role in the inflammation and tissue damage associated with these conditions.

Interactions

IL-20 interacts with two receptors, IL-20R1 and IL-20R2. These receptors are expressed on the surface of cells and bind to IL-20, triggering a series of intracellular events that lead to the biological effects of this cytokine.

External links

• IL20 Gene - NCBI
• Interleukin-20 - UniProt