Interleukin 9 receptor

Interleukin 9 receptor (also known as IL9R) is a type of protein that in humans is encoded by the IL9R gene. It is a member of the interleukin receptor family, which plays a crucial role in the immune system.

Function

The IL9R protein is a receptor for interleukin 9 (IL9), a cytokine (a type of signaling molecule) involved in various biological processes. The binding of IL9 to this receptor can lead to the proliferation and survival of certain cell types, including T cells and mast cells. This receptor is also involved in the regulation of immune responses and inflammation.

Structure

The IL9R protein is a type of transmembrane protein, meaning it spans the entire cell membrane. It is composed of an extracellular domain, which binds to IL9, a transmembrane domain, and an intracellular domain, which transmits the signal into the cell.

Clinical significance

Mutations in the IL9R gene can lead to immunodeficiency conditions, such as X-linked severe combined immunodeficiency (X-SCID). Additionally, overexpression of IL9R has been associated with certain types of cancer, including leukemia and lymphoma.

See also

• Interleukin 9
• Interleukin receptor
• Cytokine
• Immune system

References

‎

‎ ‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian