Internexin
Internexin is a type of protein that in humans is encoded by the INA gene. It is a neuronal intermediate filament protein that is expressed in a wide variety of neuronal cells and tissues. Internexin may function in maintaining the shape and stability of nerve cells and may play a role in neuronal development and regeneration.
Function[edit | edit source]
Internexin is a 66-kD neuronal intermediate filament protein that is expressed in a wide variety of neuronal cells and tissues. It is believed to function in maintaining the shape and stability of nerve cells and may play a role in neuronal development and regeneration. Internexin is a major component of the cytoskeleton, which is a network of fibers that make up the cell's structural framework. The cytoskeleton has several critical functions, including determining cell shape, enabling cell movement, and playing important roles in both cell division and cell signaling.
Clinical significance[edit | edit source]
Mutations in the INA gene have been associated with a variety of neurological conditions, including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In addition, abnormal accumulation of internexin has been observed in the brain tissue of individuals with these conditions.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- INA at the National Center for Biotechnology Information
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Contributors: Prab R. Tumpati, MD
