Intracerebroventricular injection

Intracerebroventricular injection is a method used in neuroscience to inject substances into the brain ventricles. This technique allows for the direct delivery of drugs or other substances to the central nervous system.

Overview[edit | edit source]

Intracerebroventricular injection (ICV) is a procedure that involves injecting a substance directly into the brain's ventricular system. This is often done to bypass the blood-brain barrier, which can prevent certain substances from reaching the brain when administered through more traditional routes.

Procedure[edit | edit source]

The procedure for an ICV injection typically involves the use of a stereotaxic apparatus to ensure accurate placement of the injection needle. The substance to be injected is then delivered directly into the ventricular system.

Applications[edit | edit source]

ICV injections are used in both research and clinical settings. In research, they can be used to deliver substances such as neurotransmitters, neurotrophic factors, and pharmacological agents directly to the brain. Clinically, ICV injections can be used to deliver chemotherapy drugs to treat brain tumors, or to deliver antibiotics to treat brain infections.

Risks and Complications[edit | edit source]

As with any invasive procedure, ICV injections carry some risks. These can include infection, bleeding, and damage to brain tissue. In addition, the injected substance may have side effects or cause an allergic reaction.

See Also[edit | edit source]

Intracerebroventricular injection Resources
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