Iron dextran complex
A colloidal solution containing ferric oxyhydroxide complexed with polymerized dextran.
Clinical use[edit | edit source]
It is used as a form of parenteral iron-replacement therapy.
How does it work?[edit | edit source]
Upon administration and absorption, the iron dextran complex is removed from plasma by the reticuloendothelial system which cleaves it into the components iron and dextran; ferric iron subsequently binds to transferrin or is stored as hemosiderin or ferritin.
Transport in the blood[edit | edit source]
Transferrin-bound iron is transported in the plasma to the liver, spleen and bone marrow, where is it is incorporated into hemoglobin (Hgb) and to muscle where it is incorporated into myoglobin (Mb).
Benefits[edit | edit source]
Use of this agent circumvents the gastrointestinal adverse effects commonly encountered with the use of orally administered iron salt preparations.
Side effects[edit | edit source]
Because of cross-reactivity with antibodies targeted against polysaccharides similar to dextran, anaphylactic reactions may occur with this type of iron formulation.
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