Irvine Page
Irvine Heinly Page (January 7, 1901 – June 10, 1991) was an influential American physiologist and biochemist known for his groundbreaking research in hypertension and neurochemistry. His work significantly advanced the understanding of the biochemical mechanisms underlying high blood pressure and led to the discovery of several important substances in the blood that play a role in regulating blood pressure and brain function.
Early Life and Education[edit | edit source]
Irvine Page was born in Indianapolis, Indiana. He pursued his undergraduate studies at Amherst College, where he developed an interest in biology and chemistry. After completing his bachelor's degree, Page went on to earn his medical degree from the Johns Hopkins University School of Medicine, where he was influenced by the burgeoning field of biochemistry.
Career and Research[edit | edit source]
After completing his medical degree, Page embarked on a career that would see him make several seminal contributions to medical science. He began his research career at the Mayo Clinic in Rochester, Minnesota, where he focused on the chemistry of the brain. His early work involved the study of brain lipids and their role in neurological disorders.
Page's most notable contributions came after he moved to the Cleveland Clinic in 1945, where he served as the head of research. It was here that he discovered serotonin, a neurotransmitter that plays a key role in regulating mood, appetite, and sleep. This discovery opened new pathways in the study of psychiatric disorders and their treatment.
In addition to his work on serotonin, Page is renowned for his research into the mechanisms of hypertension. He was instrumental in the discovery of angiotensin, a peptide hormone that constricts blood vessels and raises blood pressure. He also identified the enzyme renin, which plays a crucial role in the body's regulation of blood pressure. These discoveries have had a profound impact on the treatment of hypertension and heart disease, leading to the development of a new class of drugs known as ACE inhibitors.
Legacy[edit | edit source]
Irvine Page's contributions to medicine and biochemistry have been widely recognized. He received numerous awards and honors throughout his career, including the Albert Lasker Award for Basic Medical Research. He was a founding member of the American Society for Hypertension and served as its first president.
Page's work laid the foundation for much of the modern understanding of cardiovascular and neurological diseases. His research has helped to save or improve the lives of millions of people worldwide.
Selected Publications[edit | edit source]
Throughout his career, Page authored and co-authored numerous scientific papers and books that have been influential in the fields of neurochemistry and cardiovascular research. Some of his most notable publications include studies on the isolation and function of brain peptides, the role of renin and angiotensin in hypertension, and the biochemical basis of mood disorders.
Death[edit | edit source]
Irvine Page passed away on June 10, 1991, leaving behind a legacy of scientific achievement that continues to influence the fields of biochemistry and medicine.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD