Isoflupredone

Isoflupredone is a synthetic glucocorticoid, a class of corticosteroids that are involved in a wide range of physiological processes including the regulation of metabolism, immune response, and inflammation. It is used in veterinary medicine for its anti-inflammatory and immunosuppressive effects.

Pharmacology[edit | edit source]

Isoflupredone, like other glucocorticoids, acts by binding to the glucocorticoid receptor, a type of nuclear receptor that is activated by binding of its ligand. This binding induces a conformational change, leading to the dissociation of heat shock proteins, transport through the cell membrane, and binding to glucocorticoid response elements in the DNA, leading to changes in gene transcription.

Uses[edit | edit source]

In veterinary medicine, isoflupredone is used for its anti-inflammatory and immunosuppressive effects. It is used to treat a variety of conditions, including allergies, autoimmune diseases, and inflammation. It is also used to suppress the immune system in animals with autoimmune diseases or following organ transplantation.

Side effects[edit | edit source]

Like other glucocorticoids, isoflupredone can have a number of side effects. These can include increased thirst and urination, increased appetite, weight gain, and behavioral changes. Long-term use can lead to more serious side effects, including Cushing's syndrome, diabetes mellitus, and osteoporosis.